You may be familiar with baclofen as its brand name Lioresal. This drug is a central nervous system depressant, most often used as a skeletal muscle relaxant to treat conditions like spasticity.
This drug may seem like an odd choice for someone chasing a high, as research has shown that it produces no euphoric feeling, nor does it inspire any cravings. In fact, a 2013 study from the journal European Addiction Research found that baclofen may even be an effective medication treatment for alcohol withdrawal. While baclofen’s efficacy in the treatment of withdrawal is still up for debate, there is conclusive evidence that mixing baclofen and alcohol can be incredibly dangerous.
Another reason one might mix baclofen and alcohol is the effect baclofen has on withdrawal. A 2009 study in Alcoholism: Clinical and Experimental Research concluded that “[b]aclofen alone has minimal abuse liability in heavy social drinkers.” This research may persuade someone going out for a drink with friends to combine their drink with the drug in the hopes that they will be able to avoid overdoing it or having a hangover the next morning.
This is known as a pharmacodynamic interaction, which Alcohol Research & Health defines as an interaction “in which alcohol enhances the effects of the medication, particularly in the central nervous system.”
If you, or a loved one, have been prescribed baclofen for any condition, refrain from alcohol while taking the medication. Simply put, the risk is just too great.