- Phenobarbital and other epilepsy treatments
- Hormonal contraceptives
One of the most dangerous interactions involves mixing Suboxone and benzodiazepines. These fast-acting anti-anxiety medications, like Klonopin, Xanax, and Valium, are notorious for enhancing the effects of other drugs, such as prescription narcotic painkillers or alcohol. In fact, a combination of any two, or all three, of these drugs can lead to hospitalization. The DAWN Report showed that, between 2005 and 2011, almost 1 million people went to the hospital for emergency medical attention due to any combination of opioids, benzodiazepines, and alcohol.
Although buprenorphine is a partial opioid agonist, and not a full agonist like hydrocodone or oxycodone, it can still create euphoria like harder narcotics do if a person can enhance the drug’s effects. Often, this involves taking a lot of buprenorphine or getting the full dose all at once. A person could also mix benzodiazepines and Suboxone, which bypasses the naloxone, and get very intoxicated from the buprenorphine. This practice can quickly lead to overdose.