How Long Does Vyvanse Stay in Your System?

1 min read · 4 sections
Vyvanse (lisdexamfetamine dimesylate) is a stimulant medication that is approved by the U.S. Food and Drug Administration (FDA) for the treatment of attention deficit hyperactivity disorder (ADHD) and moderate to severe binge eating disorder (BED). The drug is approved for use in individuals over 6 years old for ADHD and over 18 years old for BED. Vyvanse is not approved for weight control, to assist with weight loss, or for the treatment of obesity, like many central nervous system stimulants are—although some individuals may use it in this capacity.

Vyvanse detection in the body depends on a variety of factors, including the drug test administered.
What you will learn:
What Vyvanse is
Its effect and duration
What impacts the length of time Vyvanse remains in the system
Getting help for Vyvanse addiction

What is Vyvanse?

Vyvanse is a controlled substance, classified by the United States Drug Enforcement Administration (DEA) in the Schedule II categorization of controlled substances. It requires a prescription from a physician. Stimulants like Vyvanse may often be used by physicians for off-label purposes, such as to counteract lethargy, address hypoactive delirium, or even as an aid to improve focus for individuals with neurological issues that result in cognitive problems. Because of the way that Vyvanse is metabolized in the system, it may be less likely to be used for these purposes than other stimulants.

Vyvanse Effect and Duration

The length of time that a drug remains in an individual’s system is often estimated or measured by the drug’s half-life (the time it takes normal metabolic processes to reduce the concentration of the drug by half).

Lisdexamfetamine, the active ingredient in Vyvanse, is naturally metabolized into the stimulant dextroamphetamine.

How long these substances stay in a person’s system depends on a number of factors, including:

  • How often the person took Vyvanse.
  • The dose taken.
  • Whether Vyvanse was taken in conjunction with another substance.
  • When the person last took Vyvanse.
  • Their weight and gender.
  • The presence of physical health conditions.

How Long Does Vyvanse Last in the System?

Vyvanse was originally believed to have a lower potential for misuse compared to other prescription stimulant drugs like methylphenidate (e.g., Ritalin). However, research suggests that Vyvanse is a potential drug of misuse.

The detectability of any drug in a person’s system depends on numerous factors as previously mentioned above.

Employers, law enforcement, medical and mental health professionals, and sports organizations typically use blood or urine—and sometimes hair—tests to assess the presence of certain substances in an individual’s system.

Getting Help for Vyvanse Addiction

If your misuse of Vyvanse has turned into an addiction, substance use treatment programs can help you or someone you love.

In a comprehensive treatment program—which may take place in an inpatient or outpatient setting—you receive individual and group counseling, psychoeducation, and behavioral therapies, such as cognitive-behavioral therapy (CBT). Cognitive-behavioral therapy teaches you coping skills to help you identify your triggers, manage your stressors, and adjust your thoughts and behaviors to stop your Vyvanse use and prevent relapse.

Call American Addiction Centers at to speak to one of our knowledgeable and compassionate admissions navigators, who can listen to your story, explain your options, answer your questions, and help you get on your path to recovery.

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