Diazepam, most commonly recognized under the trade name Valium (but it is also sold under a large number of other trade names), is a member of the benzodiazepine medication class. Valium is one of the best recognized drugs in the world and at one time was the best-selling drug in the United States. It is used to treat anxiety and anxiety disorders, treat withdrawal syndromes to other benzodiazepines and alcohol, manage seizures, treat restless leg syndrome, treat muscle spasms, and in the treatment of insomnia. Due to its high potential for abuse and addiction, it is no longer a first line choice in the treatment of anxiety, but still continues to be used for a number of treatment options.
This makes them particularly hard to stop using without professional help.
It is also important to note that even though physical dependence is considered to be a symptom of a substance use disorder (drug abuse or addiction), physical dependence on any drug is neither necessary nor sufficient to be diagnosed with a substance use disorder. Many individuals use drugs under the supervision of a physician for medicinal purposes for lengthy periods of time and develop a physical dependence on them; however, they do not abuse the drugs (use them for nonmedical reasons), and they technically do not qualify for a diagnosis of addiction (which is a syndrome of nonmedical drug use that leads to a number of dysfunctional consequences). Thus, an individual who is using Valium for seizure control under the supervision of a physician and uses it within the prescribed boundaries will inevitably develop physical dependence over time, but the individual would not be diagnosed with a Valium use disorder (addiction or abuse to Valium).
People who demonstrate withdrawal from Valium may or may not qualify for an abuse or addiction diagnosis; however, the withdraw process follows a relatively similar progression in most individuals, with some deviation due to individual differences. Withdrawal from benzodiazepines has been described in research literature based on the clinical observations of patients’ benzodiazepine addictions. The classic and most enduring model of Valium/benzodiazepine withdrawal is a stage model that includes two basic withdrawal stages. The stages are differentiated by the number and intensity of the symptoms and their length:
Acute stage: About 1-4 days following a person’s last use of Valium, the individual will begin to experience the effects of acute withdrawal. Valium has a variable half-life that can be as high as 48 hours, so for some individuals there may be no significant symptoms for a day or so, but by day 3-4, the person will begin to experience acute withdrawal symptoms. The determination of how soon after stopping Valium these symptoms will appear depends on how much and how often the person took Valium, the length of time Valium was abused, whether or not other drugs were also abused, and individual differences in metabolism and emotional and psychological stability. For instance, some individuals who are prone to anxiety and depression may begin to experience rebound anxiety (a return of the anxiety that was present before the person started taking the drug) after a relatively short period of not using Valium.
General withdrawal: After a period of 3-4 days of acute symptoms, the person will tend to experience a more lengthy withdrawal phase that will continue for 10-14 days in most cases. During this period, the person will experience increased cravings for Valium, lightheadedness, mild headache, mild fever, periods of nausea, potential chills, depression, and continuing bouts of anxiety. These symptoms will be significantly less intense than the acute symptoms. In general, the person will experience flulike symptoms, general feelings of dissatisfaction, and an overall sense of melancholy. In some individuals, there may be an additional period of rebound anxiety between 10 and 14 days.
Following the withdraw period, individuals will slowly stabilize but may still experience issues with anxiety and depression, and general feelings of being “out of sync.”
Certain references also refer to post-acute withdrawal syndrome, which is a longer period of more generalized psychological symptoms that may occur in some individuals following recovery from drug abuse. The symptoms are typically described as issues with mood, irritability, problems experiencing pleasure to the same extent that one was able to experience pleasure prior to drug abuse, and general feelings of dissatisfaction and variable motivation. Post-acute withdrawal syndrome has been characterized as a lengthy period that can last from weeks to years that requires ongoing treatment (mostly in the form of therapy); otherwise, it can lead to an increased potential for relapse. The syndrome is not universally accepted among addiction researchers and mental health workers.
Understanding the withdrawal process from Valium is important, because individuals who are going through withdrawal are at a higher risk for relapse. The sudden appearance of rebound anxiety and physical symptoms can be almost immediately countered if the individual begins to take Valium again. This makes it extremely difficult for individuals to discontinue Valium “cold turkey” on their own without professional assistance.
Other medications that might be used include the following:
Other specific medications for nausea, headache, and so forth can be added at a physician’s discretion.