The barbiturate phenobarbital is marketed under several different brand names, including Luminal and Nembutal. Barbiturates make up a class of drugs that act as central nervous system depressants, meaning they suppress the actions of the neurons in the brain and spinal cord.
Their primary mechanism of action is to increase the efficiency and availability of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). When activated, this neurotransmitter has the effect of inhibiting the firing of other neurons in the central nervous system.
Most of the prescriptions written for phenobarbital are for seizure control.
Information provided by the Substance Abuse and Mental Health Services Administration (SAMHSA) indicates that barbiturates are not as freely prescribed as they were before the development of benzodiazepines. Abuse of barbiturates often occurs in younger individuals who procure the drug by stealing it or getting it from someone who has a prescription for the drug. According to the data from 2015, approximately 0.6 percent of individuals over the age of 12 reported abusing sedative medications; SAMHSA lists benzodiazepines, barbiturates, and certain sleep aids under the title of “sedatives.” However, the vast majority of individuals who are prescribed these medications (nearly 85 percent) do not abuse them.
Using phenobarbital is associated with a number of psychoactive effects. Individuals who abuse the drug often experience symptoms that are extremely similar to drinking moderate to heavy amounts of alcohol, such as being giddy, having fewer inhibitions, slurring their words, experiencing issues with motor coordination, etc. Using larger amounts of phenobarbital can result in aggressiveness, irritability, lethargy, and unconsciousness or coma.
According to the American Psychiatric Association (APA), someone who develops a substance use disorder as a result of using a barbiturate would be classified with a hypnotic, sedative, or anxiolytic use disorder. Some of the signs that an individual is abusing a barbiturate like phenobarbital may include the following:
Based on the diagnostic criteria for a substance use disorder from APA, the warning signs that an individual is developing a formal substance use disorder as a result of phenobarbital abuse might also include:
Although a formal substance use disorder can only be diagnosed by a licensed mental health clinician, when anyone notices two or more of the above signs or symptoms, it’s important to discuss the situation with the person and suggest that they seek professional help.
Aside from the development of a substance use disorder, there are several other potential risks associated with using or abusing phenobarbital, even at prescribed doses, for significant periods of time. Research has indicated the following:
Finally, individuals who abuse a drug like phenobarbital are at extreme risk to suffer severe overdose effects. Overdose from phenobarbital is potentially dangerous; remember that phenobarbital has been used in lethal injections in the United States and other countries. Abusing phenobarbital with other substances increases this risk.
A person who has developed a substance use disorder as a result of phenobarbital abuse has a serious mental health condition that requires formal intervention. The withdrawal process from phenobarbital may result in the development of seizures, and the seizures can actually be fatal. Therefore, it is extremely important that anyone who has abused phenobarbital on a regular basis consult with a licensed physician before discontinuing use of the drug.
The first step of recovery from phenobarbital abuse for most individuals would be placement in a formal physician-assisted withdrawal management program to help the individual safely discontinue use of the drug and avoid any potentially serious withdrawal symptoms. The physician will prescribe medications, most likely a benzodiazepine or another barbiturate, and then slowly taper down the dosage of that drug while monitoring the client. This will allow the individual to be slowly weaned off the drug safely. It is important to understand that individuals cannot safely and effectively undergo a withdrawal management program without being under the supervision of an addiction medicine physician or a psychiatrist who specializes in addiction medicine.
Simply going through the withdrawal process is not sufficient to recover from a substance use disorder. The foundation of recovery from any substance use disorder is engagement in a formal substance use disorder treatment program that includes therapy as its main component. Substance use disorder therapy helps the individual address the issues that drove their substance abuse, rectify these issues, learn positive coping skills, and develop a long-term plan of relapse prevention. The preferred form of therapy for substance abuse treatment is some form of Cognitive Behavioral Therapy. Therapy can be delivered in the form of individual therapy, group therapy, or in a combination of both individual therapy sessions and group therapy sessions.
In addition to therapy, other useful interventions include participation in social support groups (e.g., 12-Step groups), interventions aimed at helping individuals with education or occupational skills, and adjunctive and complementary interventions, such as music therapy, art therapy, animal-assisted therapy, etc. Any co-occurring psychological disorders or medical conditions should also be treated in conjunction with the individual’s substance use disorder.
Successful treatment outcomes for substance use disorders are highly related to the length of time individuals remain in these interventions. Individuals who remain in therapy and continue to participate in social support groups following the completion of formal treatment have the best chances of overall success.