Guide to Drug Use & Infectious Diseases Within the Gay Community

5 min read · 7 sections
Evidence-Based Care
Expert Staff

Members of the gay community who use drugs can lower their risk of infection by practicing safe sex, using clean needles, getting vaccinated, and avoiding drugs and alcohol in association with sexual activity.

Risks for Contracting Diseases

Members of the LGBT community use substances at higher rates than the heterosexual population.

Higher rates of substance use among the LGBT population may be attributed to a reaction to homophobia, violence, or discrimination related to their sexual orientation.3

The use of drugs and alcohol impairs your judgment, which may increase the likelihood of risky sexual behaviors (such as having multiple partners or not using a condom).4 These behaviors, as well as sharing needles and other injection equipment, put you at an increased risk of contracting serious illnesses such as HIV.3

The rest of this article will examine some of the specific illnesses that can be contracted or transmitted through drug use among the LGBT community, as well as ways to prevent infection.


HIV stands for human immunodeficiency virus, which is the virus that can lead to AIDS (acquired immunodeficiency syndrome) if left untreated. HIV is a virus that attacks the body’s immune system, or more specifically, the CD4 cells (T cells) that are responsible for keeping us healthy. When HIV attacks the T cells, it makes it difficult for your body to fight off infections because your immune system is weakened. Certain types of cancers and opportunistic infections are then able to take advantage of your compromised immune system.7

HIV is particularly prevalent among gay and bisexual men who have sex with men. Roughly 69% of people diagnosed with HIV in 2019 in the United States were gay and bisexual men.8


Most gay and bisexual men get HIV by having unprotected anal sex or without consistently using HIV pre-exposure prophylaxis.8

People under the influence of drugs such as heroin and cocaine may also be more likely to engage in risky sexual behaviors that can expose them to HIV.4



Other STDs

Other STDs prevalent in the LGBT community include syphilis, gonorrhea, chlamydia, and HPV. Having a symptomatic STD can further increase your chances of acquiring HIV through unprotected sex.9


Syphilis is a bacterial infection that you can acquire through a cut in the skin or by contact with another person’s syphilis lesion, usually during sexual contact.9, 10 If left untreated, syphilis can cause significant damage to vital organs. Complications can include damage to the heart, nervous system, brain, and death.10

Gonorrhea and Chlamydia

Gonorrhea and chlamydia are both bacterial infections of the genital region. Both are spread through oral, anal, and vaginal sex.10

However, if you are a woman and have chlamydia, you can experience vaginal discharge, burning, painful urination, and bleeding. If you are male, you may experience discharge, itching, or burning and pain when urinating.10

Gonorrhea infections may also not cause any symptoms. But they are sometimes associated with burning upon urination, as well as vaginal or penile discharge. Women can have vaginal bleeding or pelvic pain, and men may have painful or swollen testicles.10

If left untreated, both gonorrhea and chlamydia can cause pelvic inflammatory disease (PID) in women, which can increase the risk of infertility and ectopic pregnancy. Men can develop a painful condition called epididymitis, which can lead to infertility. Babies born with either disease can develop eye infections, and babies born to infected moms with chlamydia can develop lung infections.10

Both conditions are treated with oral antibiotics that cure the infection. Both sexual partners must be treated at the same time to avoid passing the infection back and forth, and they should avoid sex until the infection is completely gone.10


HPV, also known as human papillomavirus, is a viral infection with more than 40 subtypes that can affect the genitals. Papillomaviruses can be transmitted through oral, anal, and vaginal sex.10

Symptoms can be severe and uncomfortable, but often there are no symptoms at all. Genital warts can develop in association with some types of HPV. Other HPV subtypes are associated with certain cancers, which are frequently asymptomatic until advanced stages. Babies born to women with HPV can develop warts in their throat, and adults can develop cervical and anal cancer if the infection goes untreated for many years.10


Infection with the various hepatitis viruses can result in severe liver inflammation. The three most common types of infection are caused by viruses known as hepatitis A, hepatitis B, and hepatitis C. While there are some commonalities among these 3 types, they are distinctive in how they are spread.11

Treatment recommendations for all types of viral hepatitis include avoiding the use of alcohol. Vaccinations for hepatitis A and hepatitis B can prevent infection from these two virus types.11

Hepatitis A

Hepatitis A (HAV) is found in human feces and is usually spread through close contact, whether it be through sex or by living in the same household and sharing food or water. If you travel to areas of the world where HAV is prevalent, you may be at risk of catching the virus. Once you catch hepatitis A, you can’t catch it again.11

There is no treatment for this type of hepatitis—only managing symptoms. Fifteen out of 100 people infected will have a long-term illness or recurring symptoms over a 6- to 9-month timespan.11

Hepatitis B

Hepatitis B (HBV) is found in bodily fluids and blood, and can be spread through unprotected sex, sharing needles during drug use, or exposure to sharps (needles and other sharp objects) on the worksite.11

Medications may prevent serious liver issues in up to 40% of people. However, between 2,000 to 4,000 people die each year in the U.S. from the disease. Chronic liver disease, liver cancer, liver failure, and death are possible, especially if the disease is left untreated. Death from chronic liver disease occurs in 15% to 25% of infected people. A liver transplant may be used in cases of severe liver disease.11

Hepatitis C

Hepatitis C (HCV) is found in bodily fluids and blood and is spread through exposure to sharps, sharing needles, or from a mother to her baby during birth. Sex is an uncommon method of transmission.11

There is no medication to treat recently acquired HCV. But chronic HCV can be treated with medications. People who have the infection should be checked for liver disease every 6-12 months. Seventy-five percent to 85% of newly infected people develop chronic infection, and 70% of chronically infected people develop liver disease. People who have a chronic infection are at a higher risk of liver failure and liver cancer. About 8,000 to 10,000 people die every year from HCV.11

Other Infections

Infective endocarditis (IE) is an inflammation of the endocardium, which is a membrane that lines the chambers of the heart. It has been recognized as a consequence of IV drug use as far back as the 1950s. IE is more common in HIV-infected IV drug users than IV drug users who do not have HIV.12,13

IE is most commonly caused by bloodborne bacteria and can ultimately result in damaged heart valves, if not treated effectively.13

IE is treatable with high-dose antibiotics, but some people may require surgery.13

Tuberculosis (TB) is a disease caused by mycobacteria that can infect various parts of the body, but often attack the lungs. It is spread through the air by a person coughing, sneezing, or speaking.14 Drug use has been associated with a higher incidence of TB infection.15

TB is usually treated with a combination of several medications taken over an extended period of time. It can be fatal if untreated.14

Addiction Treatment

In addition to reduced drug use, treatment for substance use disorders is associated with less risky sexual behavior among men who have sex with men.1

Addiction treatment often begins with a period of detoxification to rid your body of drugs and toxins. Once you are medically stable, you may move on to formal treatment that could include a combination of behavioral therapy and medication.

Treatment plans can be tailored to your individual needs. If you are a member of the LGBT population, research shows you could benefit from specialized treatment that addresses unique factors such as homophobia/transphobia, violence, family issues, and social isolation that are commonly experienced by members of your group.1

Specific therapies have been particularly effective for bisexual or gay men include social support therapy, motivational interviewing, cognitive behavioral therapy (CBT), and contingency management.1


There are specific things you can do to reduce or even prevent your risk of contracting certain infectious diseases.

According to the Centers for Disease Control and Prevention, there are currently 35 states as well as the District of Columbia that have such programs.17

If you or someone you know is struggling with drug use and may be at risk of an STD or other disease, reach out for help today. There are rehab centers around the country that can help you overcome your addiction and learn how to live a drug-free life.

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