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How Are Dissociative Disorders Treated Alongside Substance Use?

4 min read · 6 sections
A person’s sense of identity, feelings, and memories make up a huge part of who they are as a human being, but for those who suffer from dissociative disorders, these can be significantly disrupted. This disruption may lead to severe impairment in many areas of a person’s life. Dissociative disorders are commonly linked to a prior trauma experience, e.g., childhood abuse.1

What are Dissociative Disorders?

Dissociative disorders are characterized by an involuntary escape from reality characterized by a disconnection between thoughts, identity, consciousness, and memory.2 Dissociation, in itself, is a common phenomenon. Research indicates that as many as 75% of individuals have experienced at least one episode of dissociation/derealization at some point in their lives. For example, if you’ve ever driven home and realized you can’t remember your drive, you probably dissociated to some degree on your drive.1,2 However, only 2% of those individuals meet the full criteria for chronic episodes.2

Dissociation is a common response to trauma. Some individuals, who experience a traumatic event—such as an accident or a violent crime—may experience dissociation, which provides a psychic escape when there is no physical escape. Dissociation is generally associated with increased symptom severity across diagnoses and higher psychiatric relapse rates.3

Types of Dissociative Disorders

There are three types of dissociative disorders defined by the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). These include:2

  • Dissociative amnesia. This condition may involve not remembering or having incomplete memories of a specific event or events (such as abuse or military combat), or it may involve the loss of memory about a great deal of the person’s life or identity.
  • Depersonalization/derealization disorder. This disorder is marked by a sense that one’s life, thoughts, feelings, actions, and/or sensations are separate from oneself, as though they are watching a movie (depersonalization). Sometimes the person’s surroundings may feel unreal (derealization). Sometimes, a person experiences depersonalization, derealization, or both.
  • Dissociative identity disorder. Previously called multiple personality disorder, this condition involves the person alternating between separate and distinct identities. Dissociative identity disorder may involve large gaps in memory and an inability to recall everyday events, personal information, or traumatic experiences.

Often, dissociative disorders develop as a result of overwhelmingly traumatic experiences. Studies indicate that the lifetime prevalence of dissociative disorders ranges from about 9% to 18%.3

Typically, dissociative disorders develop as a coping mechanism, as a way to separate oneself from trauma. Dissociative disorders often form in children, whom are exposed to long-term physical, sexual, or emotional abuse—though they may also develop as a result of natural disasters and combat.2

Additionally, trauma-induced dissociative disorders commonly co-occur with other mental health disorders, including:2,4

Understanding Dissociative Disorders

While there are several types of dissociative disorders (see below), general symptoms of disorders that fall under this umbrella include:5

  • Significant lapses in memory.
  • Feeling outside your body, as though watching events of your life instead of experiencing them.
  • Feeling emotionally detached/numb.
  • A lack of personal identity.

Complications of Dissociative Disorders

Dissociative disorders are associated with a heightened risk for several issues, including:7

  • Problems with sleep, such as insomnia, nightmares, and sleepwalking.
  • Major problems with personal relationships and/or at work
  • Eating disorders.
  • Post-traumatic stress disorder (PTSD).
  • Anxiety disorders.
  • Depression.
  • Personality disorders.
  • Physical symptoms, including non-epileptic seizures and/or lightheadedness
  • Problems with sexual functioning.
  • Substance use disorders.
  • Self-harm.
  • Suicidal thoughts and actions.

Dissociative Disorders and Addiction

Individuals with dissociative disorders may turn to substances as a further escape from their trauma when their disorder does not provide adequate relief.8 Using psychoactive substances, however, can cause additional harm and may lead to a co-occurring substance use disorder.

In 1999, an article was published in the Journal of Psychoactive Drugs about “the forgotten relationship” between dissociative identity disorder and substance abuse. Specifically, substance use and dependence were among the most common diagnoses in patients with dissociative identity disorder. Practitioners who primarily treat individuals struggling with substance dependence and addiction may care for patients who have DID but fail to recognize the condition.9

Treating Dissociative Disorders and Substance Use Disorders

How are dissociative disorders treated alongside substance use disorders? The first step is that both conditions have to be diagnosed. Assessing the patient and making a diagnosis, however, may be difficult, especially in a patient with shifting identity states. Clinicians will generally work with the patient to gather their psychosocial history, including any history of trauma. Other steps may include an intelligence test, personality test(s), questions to determine the individual’s own perception of their dissociation, and an interview to evaluate the individual for dissociative disorders.10 Substance use also complicates the assessment process, so patients may need to be reevaluated after a period of abstinence in order to separate the effects of substance use and/or withdrawal from the symptoms of a co-occurring mental illness.11

Treating dissociative disorders usually requires psychotherapy. Treatment for dissociative disorders aims to address both the symptoms of the disorder and the trauma that caused the development of the disorder. Although there are no medications that directly treat dissociation, medications may be used to treat other symptoms or to treat any other conditions occurring alongside the dissociative disorder, such as PTSD, depression, or anxiety.5

If a patient presents with both a dissociative and a substance use disorder, simply treating the drug abuse without giving any attention to the dissociative symptoms and their cause is likely to be much less beneficial for the patient’s long-term well-being and mental health.2

One of the key elements of treating dissociative disorders and/or substance use disorders is participation in therapy sessions. For patients who present with dissociative disorders, working with a therapist to deal with any past trauma and to learn coping skills can be enormously beneficial. However, a patient with a dissociative disorder should seek a therapist who has experience and/or training in trauma therapy.7 Psychotherapy is also important in drug abuse treatment; not participating in treatment after detoxification often leads to relapse, and therapy can be an effective treatment for substance use disorders.12,13 Patients who present with co-occurring disorders should get integrated treatment, which provides better results.14 Entering a drug addiction rehab program that is ill-equipped to handle co-occurring disorders may do little to help individuals with them.


Cognitive behavioral therapy (CBT) is used in the treatment of both dissociative disorders and substance use disorders. Per the National Alliance on Mental Illness, CBT works by helping patients recognize and change negative thoughts and behaviors.5 CBT is thought to be effective for dissociative identity disorder and may be effective for other dissociative disorders as well.15 Studies have demonstrated that CBT is effective for substance use disorders.16

Other types of psychotherapy that may be used to treat dissociative disorders include:5,17

  • Dialectical behavior therapy (DBT). This therapy seeks to help individuals find balance between acceptance and change. It can help decrease destructive behaviors. Individuals learn skills to control their emotions, including techniques such as mindfulness.
  • Eye movement desensitization and reprocessing (EMDR). This therapy is generally used to treat PTSD, and research shows that it can mitigate the suffering associated with traumatic memories. It helps individuals replace negative emotions in response to trauma memories with less powerful or positive responses.

Medications may also be used. Although no medications directly treat dissociative disorders, medications may be used to help with some of their symptoms.7 Antidepressants and/or anxiolytics, for example, may be used to treat depression and anxiety symptoms. Antipsychotics may be used to stabilize mood and alleviate intrusive symptoms, psychotic symptoms, and excessive anxiety.18 Treatment of substance use disorders may also involve medication;12 however, the treatment team should be careful not to prescribe any medications that will cause dangerous interactions with other medications.

Dissociation, Addiction, and the Future

Individuals with substance use and/or dissociative disorders should remain engaged with treatment as long as necessary. It can take a lot of time to work through dissociative disorders in therapy, especially since coping skills and a solid therapeutic relationship often need to be developed before past trauma can safely be addressed.7 For those who struggle with substance use disorders, long-term treatment or repeated episodes of treatment are often needed to sustain recovery.19 Because individuals with co-occurring disorders often have worse symptoms that are more persistent and difficult to treat, staying engaged with treatment as needed is especially important.11

Staying engaged with treatment also means continuing to take medications as prescribed. Individuals should not change their dose of medication or stop taking any medications without first discussing it with their provider, who can work together with the patient to address the patient’s concerns and find a better treatment option if needed. Suddenly changing doses or stopping medications can be dangerous: symptoms may return, withdrawal symptoms may emerge, and/or adverse effects may develop. Thus, changes should only be made under the guidance of a healthcare professional authorized to prescribe those medications. If a person thinks a medication is causing negative effects, they should contact the prescriber immediately. In an emergency, call 911.

The combination of dissociative disorders and substance use disorders can be challenging both for those experiencing the disorders and for their loved ones. But with treatment, it is possible for individuals with these disorders to learn to manage them and have great improvement in functioning.20

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