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Controlled Substances & Opioids

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  • What Are Controlled Substances?
  • How Are Drugs Classified?
  • Opiate Classifications
  • Are Opioids Controlled Substances?
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Ryan Kelley, NREMT
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Ryan Kelley is a nationally registered Emergency Medical Technician and the former managing editor of the Journal of Emergency Medical Services (JEMS).
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Jump to Section
  • What Are Controlled Substances?
  • How Are Drugs Classified?
  • Opiate Classifications
  • Are Opioids Controlled Substances?

What Are Controlled Substances?

Controlled substances are drugs that are federally regulated, based on a variety of factors.1, 2  This page will provide information on how drugs are classified, what the Controlled Substances Act is, whether opioids are controlled substances, and why they are scheduled as controlled substances. It will also discuss the various classifications of controlled substances and where different types of opioids are scheduled.

How Are Drugs Classified?

How are drugs classified? Many bottles of perception pill bottles.Drugs can be broadly classified in several ways. One of the primary classifications is between prescription medications and illicit drugs. Substances are also classified by the types of effects they have, and fall into 4 main categories:2, 3
  • Opioids, which include both the illicit drug heroin and medications commonly prescribed for pain management or cough suppression.2.
  • Central nervous system depressants, which are prescribed to manage anxiety, insomnia, treat muscle spasms, and avoid seizures.2 Depressants include benzodiazepines such as Valium and Xanax, barbiturates, as well as sleep medications such as Lunesta, Ambien, and Sonata.2 Some alternative names for depressants are downers, benzos, GHB, and roofies.2
  • Stimulants, which are prescribed to treat attention deficit hyperactivity disorder, narcolepsy, or for weight loss.2 Illicit stimulants include methamphetamine and cocaine and can produce intense euphoria, a powerful high, and improved self-esteem.2 Common street names for stimulants are coke, crack, speed, and uppers.2
  • Hallucinogens, which are not used for any medical purpose.2 This class of drugs causes changes in perception and mood, including hallucinations, and includes LSD, ecstasy, MDMA, ketamine, phencyclidine, psilocybin mushrooms, peyote, and mescaline.2 The street name for some hallucinogens are acid, mushrooms or shrooms, Special K, and STP.2

Drug scheduling is a type of classification used by the federal government for the regulation of medications and similar substances.1, 2 Drugs are classified based on various factors, including whether they have an accepted medical use and their potential for abuse.1, 2

American Addiction Centers (AAC) is the nation’s leader in substance abuse addiction treatment. Our team of medical experts provide unique care for every patient. To learn more about our addiction treatment options call us at , or schedule a call with us.

Opiate Classifications

 The Controlled Substances Act (CSA) is the federal statute establishing and defining drug policy in the U.S. It was enacted in 1970 and classifies federally regulated substances into 5 schedules.1,  2 Drug scheduling is based on whether the drug has an accepted medical use, the abuse potential of the drug, if there is a public health risk associated with the substance, the likelihood for developing a physical or psychological dependence on the substance, and if it is closely related to a drug that is already a controlled substance.1, 2 Only drugs that have the potential to be abused can be scheduled as controlled substances.2

Drugs are classified according to the following schedules:2, 4

  • Schedule I, where the substance is not approved for any medical purpose in the United States and has a high likelihood of abuse.
  • Schedule II, where the substance is approved for medical use in the United States but may have strict limitations; there is a high likelihood of abuse; and there is a risk of developing a severe physiological addiction to the substance.
  • Schedule III, where the substance is approved for medical use in the United States, the likelihood of abuse is lower than that of the substances in Schedules I and II, the risk of developing a psychological dependence is high, and the risk for developing a physical dependence is moderate to low.
  • Schedule IV, where the substance is approved for medical use in the United States, the likelihood of abuse or developing a psychological or physical dependence is lower than substances in Schedule III.
  • Schedule V, where the substance is approved for medical use in the United States, the likelihood of abuse or developing a psychological or physical dependence is lower than for substances in Schedule IV.

Did you know that American Addiction Centers has treatment facilities across the country? Your opioid addiction treatment could be covered depending on your health insurance police.

Are Opioids Controlled Substances?

Yes. All opioids are controlled substances.2 According to the CSA, opioids range in classification between Schedule I and Schedule V, depending on whether they are approved for medical use, their risk for misuse, and the likelihood of developing a physiological dependence.1, 2 Schedule I and II opioids are much more likely to be abused than Schedule V opioids.2

The risks associated with opioid use have led to their scheduling as controlled substances.2 A major risk associated with opioids is overdose.2, 3 Some forms of opioids are extremely potent and can cause overdose after ingestion of even a small amount.2 Opioid overdoses can be fatal. Deaths due to prescription pain medications increased by 5 times between 1999 and 2016.2, 3 Taking opioids more frequently, in larger doses, or in a different way than prescribed, or taking illicit opioids such as heroin, increases the risk of overdose.3

Tolerance is developed when opioids are used consistently, even under the supervision of a doctor. A person developing a tolerance may need larger amounts of the drug to experience the same effects.2, 3 Opioid use can also lead to the development of physiological dependence, which is one of the warning signs of addiction.2 The body becomes dependent on the drug, and when opioid use is stopped a person experiences symptoms of withdrawal.2, 3 Withdrawal symptoms can be very uncomfortable and painful, making it difficult to stop using opioids.3

A person who has developed a dependence may think about using opioids frequently, even after they have stopped using them, and struggle with functioning in daily life without using opioids.2 Physiological dependence frequently plays a role in relapses.2 Misusing opioids also increases the likelihood of developing an opioid use disorder.3

Schedule I Opioids

Schedule I drugs aren’t approved or accepted for medical purposes in the United States and have a high likelihood of abuse.2, 4, 5 Heroin is a Schedule I opioid, and is only used illicitly.2, 4, 5, 6 In a 2018 survey of Americans aged 12 or older, 808,000 reported using heroin in the past year.7

Opioids that are obtained through legal prescriptions for medical purposes can still be diverted and given or sold to other people.3 Prescription misuse can occur when medications are taken differently than prescribed, taken longer than originally intended, or used to get high.3

Schedule II Opioids

Schedule II drugs are approved for medical use in the United States, but a high likelihood of abuse, as well as a risk for developing a severe physiological dependence on the substance.2, 4, 5

Schedule II opioids include:2, 5, 6, 7

Fentanyl is being pressed into pills sold illicitly as painkillers, or cut into heroin or other drugs, then injected, snorted, or smoked.2 Nearly 10 million Americans aged 12 or older misused prescription opioids in 2018.7 Hydrocodone was the most commonly misused opioid in 2018, followed by oxycodone.7 The second most common form of illicit substance use in 2018 was the misuse of prescription opioids.7

Other Scheduled Opioids

Opioids that fall under Schedule III, IV, and V are approved for medical treatment in the United States and have a lower risk for abuse and psychological or physical dependence.2, 4

Some opioids in this group include:2, 5, 6

  • Buprenorphine, which is a Schedule III drug.
  • Codeine with aspirin or Tylenol, which is a Schedule III drug.
  • Cough medicines that include codeine, which are Schedule V drugs.
  • Tramadol, which is a Schedule IV drug.

Buprenorphine, which may be provided as Subutex or Suboxone, is a partial opioid agonist.5, 6, 8 It is used as part of addiction treatment programs to treat opioid use disorder and it helps to manage symptoms of opioid withdrawal, lessen the risk of overdose, and support sobriety.8 Tramadol is viewed as an atypical opioid medication that was unscheduled, but this changed in 2014.9 After gathering evidence, regulators determined that tramadol has a low risk for abuse, although it is present, and that tramadol carries a risk for developing mild psychological or physical dependence, which led the Drug Enforcement Administration to classify tramadol as a Schedule IV controlled substance.9

Opioid medications can be extremely helpful for pain management, but they are scheduled drugs that are controlled by the federal government. All opioids have a known potential for abuse. The varying scheduling of opioids can indicate the likelihood of abuse or dependence compared to other scheduled drugs. It is important to keep in mind that a person can develop a substance use disorder, which involves difficulty controlling patterns of substance use, even after experiencing harmful consequences, regardless of the schedule number the opioid is classified as.3 If you or a loved one is abusing substances of any kind, American Addiction Centers can provide effective treatment that can help. If you’ve been prescribed opioids to manage pain, American Addiction Centers can assist you in learning how to manage health issues and chronic pain as part of your treatment plan.10

 

Sources:

  1. United States Drug Enforcement Administration. The Controlled Substances Act.
  2. United States Drug Enforcement Administration. (2020). Drugs of abuse: A DEA resource guide.
  3. National Institute on Drug Abuse. (2020). Misuse of prescription drugs research report.
  4. U.S. Department of Justice. Title 21 United States Code (USC) Controlled Substances Act.
  5. U.S. Department of Justice. Controlled substance schedules.
  6. U.S. Department of Justice. (2020). Controlled substances.
  7. Substance Abuse and Mental Health Services Administration. (2019). Key substance use and mental health indicators in the United States: Results from the 2018 National Survey on Drug Use and Health. Rockville, MD: Center for Behavioral Health Statistics and Quality.
  8. Substance Abuse and Mental Health Services Administration. (2020). Buprenorphine.
  9. U.S. Department of Justice. (2014). Final rule: Placement of tramadol into Schedule IV.
  10. American Addiction Centers. (2020). Substance abuse treatment services.
Last Updated on September 11, 2020
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Ryan Kelley, NREMT
Industry Expert
Ryan Kelley is a nationally registered Emergency Medical Technician and the former managing editor of the Journal of Emergency Medical Services (JEMS).
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