Desipramine is available in its brand name of Norpramin in tablets of 10, 25, 50, 75, 100, and 150 mg. To reduce side effects, the initial dose is usually low, and it is increased as necessary until the intended effects are achieved. The maximum dose is 300 mg daily, but the usual adult dose is 100-200 mg. This can be taken every night at bedtime or, it can be divided into doses taken every 12 hours. Older people generally should take smaller doses of 25-100 mg per day.
Although some people may start feeling more alert and energetic right away, it can take up to two weeks until they start to feel better. Due to genetic differences, the rate at which people are affected by desipramine and the dose they require will vary from person to person.
The best dose is the one that provides the intended effect, and it’s acceptable to individualize your dosing regimen, with the help of your doctor, depending on what works for you. Finding the perfect dosing regimen for your system might take some time.