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Serotonin antagonist and reuptake inhibitors are primarily indicated as antidepressant medications but are more commonly used to treat other conditions such as anxiety and insomnia. Though these drugs have low potential for abuse, there have been reported cases of misuse in connection with polysubstance abuse. What Are SARIs? Serotonin antagonist and reuptake inhibitors (SARIs) are […]

What Are Tetracyclics? Tetracyclic antidepressants are used to treat major depressive disorder with symptoms such as depressed mood, feelings of worthlessness, nervousness, trouble sleeping, loss of pleasure, low energy, and suicidal thoughts.1,2 They have become less commonly prescribed, however, with the development of newer drugs. In fact, they are no longer considered a first-line treatment […]

What Are SSRIs? Selective serotonin reuptake inhibitors (SSRIs) are medications that are commonly used to treat depression, anxiety, and several other mental health issues. They are the most commonly prescribed antidepressant and are likely to cause fewer side effects than other antidepressant medications.1 SSRIs are used in the treatment of other mental health problems as […]

Many people live with depression and may take medication to manage their symptoms. There are several medications that are effective for treating depression, including NDRIs. While these drugs are effective in treating depression, their use is associated with certain side effects, withdrawal, and some risk of overdose. Though the risk is far lower than that […]

Monoamine oxidase inhibitors (MAOIs) are an older type of antidepressant medication that has largely been phased out by newer drugs such as selective serotonin reuptake inhibitors (SSRIs). They have a number of side effects and can interact with several different drugs and foods. However, they are effective in managing certain types of depression and continue […]

How Do These Drugs Work? SNRIs work by blocking the reabsorption (or reuptake) of serotonin and norepinephrine back into the nerve cells that released them, which increases the levels of active neurotransmitters in the brain.6 Both of these neurotransmitters are associated with distinct brain structures and functions and impact various processes such as mood and […]

What Are Tricyclic Antidepressants? Tricyclic antidepressants, or TCAs, were first used to manage major depression. They are believed to block the reuptake of the monoamine neurotransmitters—including serotonin and norepinephrine. The resulting increase in activity of these neurotransmitters in the brain is associated with an improvement in certain symptoms of depression. 1,2 Uses of Tricyclic Antidepressants […]

Take Our Substance Abuse Self-Assessment Take our free, 5-minute substance abuse self-assessment below if you think you or someone you love might be struggling with substance abuse. The evaluation consists of 11 yes or no questions that are intended to be used as an informational tool to assess the severity and probability of a substance […]

Depression affects millions of Americans. It is a lifelong mental health disorder that can severely impact your ability to work and engage in healthy social relationships. It is most commonly diagnosed among adults between the ages of 18 and 64, but most people experience the onset of depressive symptoms in their 20s.1 In many cases, […]

What is Paxil?: Uses & Brand Names Paroxetine, better known by the brand name Paxil, is an antidepressant medication in the selective serotonin reuptake inhibitor (SSRI) class. Paxil is used to treat conditions, such as major depression, post-traumatic stress disorder, generalized anxiety disorder, and obsessive-compulsive disorder. Paxil was first introduced in 1992 by the pharmaceutical […]