A qualified physician will determine the correct dosage for each patient. The typical dosage is one 150-mg tablet daily for three days. The dose is then increased to no more than 300 mg per day. Patients must wait eight hours between doses.
The pill should be swallowed whole and not crushed, cut, or chewed in any way. Disrupting the method of delivery in these ways can increase the risk of seizures. Bupropion can be taken with or without a meal.
Patients who have liver (hepatic) problems might have to take a lower dosage of 150 mg for their treatment. Doctors can individualize treatment with bupropion depending on the patient’s risk or past dependence on tobacco.
People with alcohol use problems, eating disorders, who are also taking medication that contains bupropion (such as Wellbutrin or its generic version), who have seizures or who have health conditions that put them at risk for receiving seizures, and who are currently taking a monoamine oxidase inhibitor (MAOI) should not take bupropion. Women who are pregnant or trying to get pregnant should consult with their doctors before taking bupropion.
The half-life of bupropion seems to depend on individual metabolisms, but it averages 21 hours, with a nine-hour margin. It takes eight days for the body to have enough bupropion to start easing the symptoms of nicotine withdrawal and reduce tobacco cravings.